What matters is the 1 seed. No matter what regional you’re in, as the 2 or the 3, you’re gonna play a good team in the first game. But if you don’t beat the 1 seed, you’re not advancing 99% of the time. People in the know like the Cajuns, and what they’ve done this year.
That said, the Cajuns are likely going to be a 2 seed. They lost a game today. They are not eliminated. Win a game tomorrow and none of this is even worth discussing.