Found this on Wikipedia:
"Playing in Houston Public School Stadium as a part of the Lone Star Conference on September 21, 1946, the Cougars played their first official game against Southwestern Louisiana Institute (later known as the University of Louisiana at Lafayette) using the Split-T offensive strategy. Although Charlie Manichia, the Cougars' starting quarterback, scored the first touchdown of the game (and in Cougar history), the team lost to SLI 13–7."