DeFeo earned All-America honors as a freshman in 1994 when she was also All-Louisiana and All-South Region, and set a school record with a .739 slugging percentage. She repeated that national honor as a sophomore when she hit .409, and took All-America honors for the third time as a senior in 1997. Twice in her career, the Ragin' Cajuns reached the World Series, and Louisiana was ranked as high as No. 2 nationally in her freshman season.