Jake Delhomme from 1A Teurlings.
Donald Richard from 2A Kaplan.
Other schools have had some pretty good ones, too.
Texas Tech's Donny Anderson from 1A Stinnet [TX] was a stud in the NFL
So was SMU and Mt. Pleasant [2A], TX QB Don Meridith.
Billy Simms is from Hooks [1A], TX
Jerry Rice is from Itta Bena, MS
Ladanlian Tomlinson played in 2A in Texas
So did Michael Clayton [in Louisiana @ Christian Life].
If I'm not mistaken, Nebraska had an Outland Trophy winner not too long ago that played 6 man football in HS.
Demetrious Hookfin from 1A Kentwood was a fairly good DB at LSU&A&MC
Small schools are not short on talented players; they are just under-recruited.