Focusing on parts rather than the whole, when it comes to genome sequencing, might be extremely useful, finds new research. The research compares several sequencing technologies in the same individual with Charcot-Marie-Tooth disease (CMT), and shows that sequencing the coding regions alone at high depth of coverage can identify the genetic variation behind this disease, and was also able to resolve previous ambiguities. Next generation sequencing for understanding human DNA variation and genetic disorders is advancing in leaps and bounds.